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Publications Fitts, R.H., J.G. Romatowski , J.R. Peters, D. Paddon-Jones, R.R. Wolfe , and A.A. Ferrando. 2007. The Deleterious Effects of Bed Rest on Human Skeletal Muscle Fibers are Exacerbated by Hypercortisolemia and Ameliorated by Dietary Supplementation. Am. J. Physiol. Cell Physiol 293: C313-C320.
Knuth, S.T., H. Dave, J.R. Peters, and R.H. Fitts. 2006. Low cell pH depresses peak power in rat skeletal muscle fibres at both 30 and 15 degrees centigrade: Implications for muscle fatigue. J. Physiol., 575:887-899. Debold, E.P., J. Romatowski, and R.H. Fitts. 2006. The depressive effect of Pi on the force-calcium relationship in skinned single muscle fibers is temperature dependent. Am. J. Physiol. Cell Physiol., 290:C1041-C1050. Trappe, T., S. Trappe, G. Lee, J. Widrick, R. Fitts, and D. Costill. 2006. Cardiorespiratory responses to physical work during and following 17 days of bed rest and spaceflight. J. Appl. Physiol., 100:951-957. Riley, D.A., J.L.W. Bain, J.G. Romatowski, and R.H. Fitts. 2005. Skeletal muscle fiber atrophy: altered thin filament density changes slow fiber force and shortening velocity. Am. J. Physiol. Cell Physiol., 288:C360 C365. Baewer, D.V., M. Hoffman, J.G. Romantowski, B.D. Curry, J.L.W. Bain, R.H. Fitts, and D.A. Riley. 2004. Passive stretch inhibits central core-like lesion formation in the soleus muscles of hindlimb-suspended unloaded rats. J. Appl. Physiol., 97:930-934. Debold, E. P., and R. H. Fitts. 2004. Fiber type and temperature dependence of inorganic phosphate: implications for fatigue. Am. J. Physiol.Cell Physiol., 287:C673-C681. Norenberg, K.M., and R. H. Fitts. 2004. Contractile responses of the rat gastrocnemius and soleus muscles to isotonic resistance exercise. J. Appl. Physiol., 97:2322-2332. Hurst, J. E., and R. H. Fitts. 2003. Hindlimb unloading-induced muscle atrophy and loss of function: protective effect of isometric exercise. J. Appl. Physiol., 95:1405-1417. Fitts, R. H. Effects of regular exercise training on skeletal muscle contractile function. 2003. Am. J. Med. Rehabil., 82:320-330. Widrick, J. J., S. W. Trappe, J. G. Romatowski, D. A. Riley, D. L. Costill, and R. H. Fitts. 2002. Unilateral lower limb suspension does not mimic bed rest or spaceflight effects on human muscle fiber function. J. Appl. Physiol., 93:354-360. Riley, D. A., J. L. W. Bain, J. L. Thompson, R.H. Fitts, J.J. Widrick, S.W. Trappe, T.A. Trappe and D.L. Costill. 2002. Thin filament diversity and physiological properties of fast and slow fiber types in astronaut leg muscles. J. Appl. Physiol., 92:817-825. Trappe, S. W., T. A. Trappe, G. A. Lee, J. J. Widrick, D. L. Costill, and R. H. Fitts. 2001. Comparison of a space flight (STS-78) and bed rest on human muscle function. J. Appl. Physiol., 91:57-64. Vijayan, K., J. L. Thompson, K. M. Norenberg, R. H. Fitts, and D. A. Riley. 2001. Fiber-type susceptibility to eccentric contraction-induced damage of hindlimb-unloaded rat Fitts, R. H., D. A. Riley, and J. J. Widrick. 2001. Functional and structural adaptations of skeletal muscle to microgravity. J. Exp. Biol., 204:3201-3208. Widrick, J.J., J.G. Romatowski, K.M. Norenberg, S.T. Knuth, J.L.W. Bain, D.A. Railey, S.W. Trappe, T.A. Trappe, D.L. Costill, and R.H. Fitts. 2001. Functional properties of slow and fast gastrocnemius muscle fibers after a 17-day spaceflight. J. Appl. Physiol., 90:2203-2211. Balog, E.M., and R.H. Fitts. 2001. Effect of depolarization and low intracellular pH on charge movement currents of frog skeletal muscle fibers. J. Appl. Physiol., 90:228-234. Fitts, R. H., D. A. Riley, and J. J. Widrick. 2000. Microgravity and Skeletal Muscle. J. Appl. Physiol., 89: 832-839. Fitts, R.H., D. Desplanches, J.G. Romatowski and J.J. Widrick. 2000. Spaceflight effects on single skeletal muscle fiber function in the rhesus monkey. Am. J. Physiol. (Reg. Int. & Comp. Physiol.), 279:R1546-R1557. Riley, D.A., J.L.W. Bain, J.L. Thompson, R.H. Fitts, J.J. Widrick, S.W. Trappe, T.A. Trappe and D.L. Costill. 2000. Decreased thin filament density and length in human atrophic soleus muscle fibers after spaceflight. J. Appl. Physiol., 88:567-572. Grichko, V.A., A. Heywood-Cooksey, K.R. Kidd and R.H. Fitts. 2000. Substrate profile in rat soleus muscle fibers after hindlimb unloading and fatigue. J. Appl. Physiol., 88:473-478. Thompson, J. L., E. M. Balog, R. H. Fitts, and D. A. Riley. 1999. Five myofibrillar lesion types in eccentrically challenged unloaded rat adductor longus muscle- a test model. Anat. Rec., 254:39-52 Widrick, J.J., S.T. Knuth, K.M. Norenberg, J.G. Romatowski, J.L.W. Bain, D.A. Riley, M. Karhanek, S.W. Trappe, T.A. Trappe, D.L. Costill, and R.H. Fitts. 1999. Effect of 17 day spaceflight on contractile properties of human soleus muscle fibers. J. Physiol. (Lond.), 516:915-930. Grichko, V.A., G.J. Gettelman, J.J. Widrick, and R.H. Fitts. 1999. Substrate and enzyme profile of fast and slow skeletal muscle fibers in rhesus monkeys. J. Appl. Physiol., 86:335-340. Widrick, J.J., K.M. Norenberg, J.G. Romatowski, C.A. Blaser, M. Karhanek, J. Sherwood, S.W. Trappe, T.A. Trappe, D.L. Costill, and R.H. Fitts. 1998. Force-velocity-power and force-pCa relationships of human soleus fibers after 17 days of bedrest. J. Appl. Physiol., 85:1949-1956. Riley, D.A., J.L.W. Bain, J.L. Thompson, R.H. Fitts, J.J. Widrick, S.W. Trappe, T.A. Trappe, and D.L. Costill. 1998. Disproportionate loss of thin filaments in human soleus muscle after 17-day bedrest. Muscle & Nerve, 21:1280-1289. Fitts, R.H., S.C. Bodine, J.G. Romatowski, and J.J. Widrick. 1998. Velocity, force, power, and Ca2+ sensitivity of fast and slow monkey skeletal muscle fibers. J. Appl. Physiol., 84:1776-1787. Widrick, J.J., J.G. Romatowski, J.L.W. Bain, S.W. Trappe, T.A. Trappe, J.L. Thompson, D.L. Costill, D.A. Riley, and R.H. Fitts. 1997. Effect of 17 days of bed rest on peak isometric force and unloaded shortening velocity of human soleus fibers. Am. J. Physiol., 273 (Cell Physiol. 42):C1690-C1699. Bangart, J.J., J.J. Widrick, and R.H. Fitts. 1997. Effect of intermittent weight bearing on soleus fiber force-velocity-power and force-pCa relationships. J. Appl. Physiol., 82:1905-1910. Widrick, J.J., J.G. Romatowski, M. Karhanek, and R.H. Fitts. 1997. Contractile properties of rat, rhesus monkey, and human type I muscle fibers. Am. J. Physiol.: Regulatory Integrative Comp. Physiol., 272:R34-42. Widrick, J.J., and R.H. Fitts. Balog, E.M., and R.H. Fitts. 1996. Effects of fatiguing stimulation on intracellular Na+ and H+ in frog skeletal muscle. J. Appl. Physiol., 81:679-685. Widrick, J.J., S.W. Trappe, D.L. Costill, and R.H. Fitts. 1996. Force-velocity and force-power properties of single muscle fibers from elite master runners and sedentary men. Am. J. Physiol.: Cell Physiol., 271:C676-683. Widrick, J.J., S.W. Fitts, R.H., and E.M. Balog. 1996. Effect of intracellular and extracellular ion changes on E-C coupling and skeletal muscle fatigue. Acta Physiol. Scand., 156:169-181. Widrick, J.J., J.J. Bangart, M. Karhanek, and R.H. Fitts. 1996. Soleus fiber force and maximal shortening velocity after non-weight bearing with intermittent activity. J. Appl. Physiol., 80:981-987. McDonald, K.S., and R.H. Fitts. 1995. Effect of hindlimb unloading on rat soleus force, stiffness, and calcium sensitivity. J. Appl. Physiol., 79:1796-1802. McDonald, K.S., C. A. Blaser, and R.H. Fitts. 1994. Force-velocity and power characteristics of rat soleus muscle fibers after hindlimb suspension. J. Appl. Physiol., 77:1609-1616. Balog, E. M., L. V. Thompson, and R. H. Fitts. 1994. Role of sarcolemma action potential and excitability in muscle fatigue. J. Appl. Physiol., 76:2157-2162. Schluter, J.M. and R.H. Fitts. 1994. Shortening velocity and ATPase activity of rat skeletal muscle fibers: effect of endurance exercise training. Am. J. Physiol.: Cell Physiol., 266:C1699-C1713. Fitts, R.H. 1994. Cellular mechanisms of muscle fatigue. Physiol., Rev. 49-94. McDonald, K.S., and R.H. Fitts. 1993. Effect of hindlimb unweighting on single soleus fiber maximal shortening velocity and ATPase activity. J. Appl. Physiol., 74:2949-2957. McDonald, K.S., M.D. Delp, and R.H. Fitts. 1992. Effect of hindlimb unweighting on tissue blood flow in the rat. J. Appl. Physiol. 72:2210-2218. Thompson, L.V., E.M. Balog, D.A. Riley, and R.H. Fitts. 1992. Muscle fatigue in the frog semitendinosus: Alterations in contractile function. Am. J. Physiol., 262:(Cell Physiol. 31):C1500-C1506. Thompson, L.V., E.M. Balog, and R.H. Fitts. 1992. Muscle fatigue in the frog semitendinosus: The role of intracellular pH. Am. J. Physiol., 262: (Cell Physiol. 31): C1507-C1512. McDonald, K.S., M.D. Delp, and R.H. Fitts. 1992. Fatigability and blood flow in the rat gastrocnemius-plantaris-soleus hindlimb suspension. J. Appl. Physiol., 73:1135-1140. Thompson, L.V., and R.H. Fitts. 1992. Muscle fatigue in the frog semitendinosus: The role of the high energy phosphates and inorganic phosphate. Am. J. Physiol., 263: (Cell Physiol. 32):C803-C809. Fitts, R.H., K.S. McDonald, and J.M. Schluter. 1991. The determinants of skeletal muscle force and power: their adaptability with changes in activation pattern. J. Biomech., 24:111-122. Fitts, R.H., D.L. Costill, and P.R. Gardetto. 1989. Effect of swim exercise-training on human muscle fiber function. J. Appl. Physiol., 66:465-475. Fitts, R.H., C.J. Brimmer, A. Heywood-Cooksey, and R.J. Timmerman. 1989. Single muscle fiber enzyme shifts with hindlimb suspension and immobilization. Am. J. Physio.,. 256:(Cell Physiol.) 25:C1082-C1091. Gardetto, P.R., J.M. Schluter, and R.H. Fitts. 1989. Contractile function of single muscle fibers following hindlimb suspension. J. Appl. Physiol., 66:2739-2749. Pizarro, G., R. Fitts, Brum, G., R. Fitts, G. Pizarro, and E. Rios. 1988. Mobile charges of the skeletal muscle membrane require calcium to function as voltage sensors of excitation-contraction coupling. J. Physiol. (Lond.), 398:475-505. Metzger, J.M., and R.H. Fitts. 1987. Role of intracellular pH in muscle fatigue. J. Appl. Physiol., 62:1392-1397. Metzger, J.M., and R.H. Fitts. 1987. Fatigue from high- and low-frequency muscle stimulation: contractile and biochemical alterations. J. Appl. Physiol. 62:2075-2082. Troup, J.P., J.M. Metzger, and R.H. Fitts. 1986. The effect of high intensity exercise-training on the functional capacity of limb skeletal muscle. J. Appl. Physiol., 60:1743-1751. Metzger, J.M., and R.H. Fitts. 1986. Contractile and biochemical properties of the diaphragm: Effects of exercise-training and fatigue. J. Appl. Physiol., 60:1752-1758. Fitts, R.H., J.M. Metzger, D.A. Riley, and B.R. Unsworth. 1986. Models of skeletal muscle disuse: A comparison of suspension hypokinesia and hindlimb immobilization. J. Appl. Physiol., 60:1946-1953. Metzger, J.M., and R.H. Fitts. 1986. High and low frequency muscle fatigue: Role of sarcolemma action potential. Exper. Neurol,. 93:320-333. Metzger, J.M., K.B. Scheidt, and R.H. Fitts. 1985. Histochemical and physiological characteristics of the rat diaphragm. J. Appl. Physiol., 58:1085-1091. Fitts, R.H., and C.J. Brimmer. 1985. Recovery in skeletal muscle contractile function after prolonged hindlimb immobilization. J. Appl. Physiol., 59:916-923. Fitts, R.H., C.J. Brimmer, J.P. Troup, and B.R. Unsworth. 1984. Contractile and fatigue properties of thyrotoxic rat skeletal muscle. Muscle & Nerve, 7:470-477. Fitts, R.H., J.P. Troup, F.A. Witzmann, and J.O. Holloszy. 1984. The effect of aging and exercise on skeletal muscle function. Mech. Aging Develop., 27:161-172. Witzmann, F.A., D.H. Kim, and R.H. Fitts. 1983. The effect of hindlimb immobilization on the fatigability of skeletal muscle. J. Appl. Physiol., 54:1242-1248. Fitts, R.H., J.B. Courtright, D.H. Kim, F.A. Witzmann. 1982. Muscle fatigue with prolonged exercise: contractile and biochemical alterations. Am. J. Physiol., 242 (Cell Physiol. 11): C65-C73. Witzmann, F.A., D. H. Kim, R.H. Fitts. 1982. Recovery time-course in contractile function of fast and slow skeletal muscle following hindlimb immobilization. J. Appl. Physiol., 52:677-682. Witzmann, F.A., D.H. Kim, and R.H. Fitts. 1982. Hindlimb immobilization: length-tension and contractile properties of skeletal muscle. J. Appl. Physiol.,. 53:335-345. Kim, D.H., F.A. Witzmann, and R.H. Fitts. 1982. The effect of disuse on the sarcoplasmic reticulum in fast and slow skeletal muscle. Am. J. Physiol., 243 (Cell Physiol. 12):C156-160. Kim, D.H., F.A. Witzmann, and R.H. Fitts. 1982. The effect of thyrotoxicosis on the sarcoplasmic reticulum in rat skeletal muscle. Am. J. Physiol., 243 (Cell Physiol. 12):C151-C155. Unsworth, B.R., F.A. Witzmann, and R.H. Fitts. 1982. A comparison of rat myosin from fast and slow skeletal muscle and effect of disuse. J. Biol. Chem., 257:5129-5136. Witzmann, F.A., J.P. Troup, and R.H. Fitts. 1982. Acid phosphatase and protease activities in immobilized rat skeletal muscle. Kim, D.H., F.A. Witzmann, R.H. Fitts. 1981. A comparison of sarcoplasmic reticulum function in fast and slow skeletal muscle using crude homogenate and isolated vesicles. Life Sci., 28:2223-2229. Kim, D.H., G. S. Wible, F.A. Witzmann, R.H. Fitts. 1981. The effect of exercise-training on sarcoplasmic reticulum function in fast and slow skeletal muscle. Life Sci., 28:2671-2677. Stefaniak, J. E., L. A. Hebert, J. C. Garancis, M. E. Sadowski, D. S. Shapiro, R. H. Fitts, J. B. Courtright. 1981. Effect of moderate daily exercise on acute glomerulonephritis. Nephron, 29: 49-54. Fitts, R.H., W.W. Winder, M.H. Brooke, K.K. Kaiser, J.O. Holloszy. 1980. Contractile, biochemical and histochemical properties of thyrotoxic rat soleus muscle. Am. J. Physiol., 238 (Cell Physiol. :C15-C20. Courtright, J.B., R.H. Fitts. 1979. Effect of thyrotoxicosis on mitochondrial enzymes of rat soleus muscle. Horm. Fitts, R.H., J.O. Holloszy. 1978. Effect of fatigue and recovery on contractile properties of frog muscle. J. Appl. Physiol., 45:899-902. Fitts, R. H., J. O. Holloszy. 1977. Contractile properties of rat soleus muscle: effects of training and fatigue. Am. J. Physiol., 233: C86-C91. Fitts, R.H., R.G. Cassens, R.G. Kauffman. 1976.Effect of exercise on porcine muscle and body composition. J. Ani. Sci., 42(4):854-85. Fitts, R.H., J.O. Holloszy. 1976. Lactate and contractile force in frog muscle during development of fatigue and recovery. Am. J. Physiol., 231(2):430-433. Fitts, R.H., F.W. Booth, W.W. Winder, J.O. Holloszy. 1975. Skeletal muscle respiratory capacity, endurance, and glycogen utilization. Am. J. Physiol., 28:1029-1033.
Winder, W.W., F.W. Booth, R.H. Fitts, J.O. Holloszy. 1975. Effect of exercise on response of liver lipogenic enzymes to a high fructose diet. Proc. Soc. Exp. Biol. and Med., 148:1150-1154. Fitch, C.D., M. Jellinek, R.H. Fitts, K.M. Baldwin, J.O. Holloszy. 1975. Phosphorylated-guanidinopropionate as a substitute for phosphocreatine in rat muscle. Am. J. Physiol., 228:1123-1125. Fitts, R.H., F.J. Nagle, R.G. Cassens. 1974. The adaptation of myoglobin with age and training and its relationship to the three fiber types of skeletal muscle in miniature pig. Europ. J. Appl. Physiol., 33:275-284. Fitts, R.H., F.J. Nagle, R.G. Cassens. 1973. Characteristics of skeletal muscle fiber types in the miniature pig and the effect of training. Canad. J. Physiol. and Pharmacol., 51:825-831. Fitts, R.H., D. Campion, F.J. Nagle, R.G. Cassens. 1973. Contractile properties of skeletal muscle from trained miniature pig. Pflügers Arch., 343:133-141. CHAPTERS IN BOOKS AND INVITED PAPERS Fitts, R.H. 2005. Chapter 8- The Muscular System: Fatigue Processes. In: Advanced Exercise Physiology, Edit. C. Tipton, Pub Lippincott Williams & Wilkins, pp.178-196. Fitts, R.H. 2004. Mechanisms of muscular fatigue. In: Principles of Exercise Biochemistry. J.R. Poortmans, Ed. Karger Pub. Vol. 46:279-300.
Fitts, R.H. 1998. Mechanisms of muscular fatigue. In: Resource Manual for Guidelines for Exercise Testing and Prescription. S.U. Blair, P. Painter, R.R. Pate, L.K. Smith, C.B. Taylor, Eds. 3rd. Edit., Lea & Ferger Pub., Philadelphia. pp. 76-82. Fitts, R.H. 1996. Cellular/molecular/metabolic basis of muscle fatigue. In: Handbook of Physiology, Section 12: Exercise: Regulation and Integration of Multiple Systems. Chapter 26: Cellular, Molecular, and Metabolic Basis of Muscle Fatigue. L.B. Rowell and J.T. Shepherd, Eds. Fitts, R.H., and J.J. Widrick. 1996. Muscle mechanics: Adaptations with exercise-training. In: Exercise and Sports Sciences Reviews, Vol. 24. J. Holloszy, Ed. Williams & Wilkins, Rios, E., A. Gonzáles, M. Karhanek, J. Ma, R. Shirokoo, G. Pizarro, L. Csernoch, R. Fitts, I. Urihe and M.Hosey. 1994. Excitation-contraction coupling in skeletal muscle. In: Bioelectrochemistry IV. B.A. Melandri (ed.). Plenum Press Publisher, pp. 225-254. Fitts, R.H., J.M. Metzger. 1993. Mechanisms of muscular fatigue. In: Principles of Exercise Biochemistry. J.R. Poortmans, Ed. Karger Pub. Vol. 38:248-268. Fitts, R.H. 1993. Mechanisms of muscular fatigue. In: Resource Manual for Guidelines for Exercise Testing and Prescription. S.U. Blair, P. Painter, R.R. Pate, L.K. Smith, C.B. Taylor, Eds. 2nd Edit., Lea & Ferger Pub., Philadelphia. pp. 106-114. Fitts, R.H. 1992. Substrate supply and energy metabolism during brief high intensity exercise. In: Perspectives in Exercise and Sports Medicine, Vol. 5. D. Lamb and C. Gisolfi, Eds. Brown and Benchmark, IN. pp. 53-106. Fitts, R.H., E.M. Balog, and L.V. Thompson. 1991. Fatigue-induced alterations in contractile function: The role of excitation-contraction coupling. In: Biochemical and Physiological Aspects of Muscle Fatigue. G. Alton, L. Beliveau, and P. Boeussou, Eds. Masson International. pp. 40-48. Rios, E., R. Fitts, Fitts, R.H., J.M. Metzger. 1988. Mechanisms of muscular fatigue. In: Principles of Exercise Biochemistry. J.R. Poortmans, Ed. Karger Pub., Vol. 27:212-22. Fitts, R.H. 1988. Mechanisms of muscular fatigue. In: Resource Manual for Guidelines for Exercise Testing and Prescription. S.U. Blair, P. Painter, R.R. Pate, L.K. Smith, C.B. Taylor, Eds. Lea & Ferger Pub., Pizarro, G., G. Brum, M. Fill, R. Fitts, M. Rodriguez, Fitts, R.H., D.H. Kim, F.A. Witzmann. 1981. The development of fatigue during high intensity and endurance exercise. In: Exercise in Health and Disease. Edit. F.J. Nagle and H.J. Montoye. Pub. C.C. Thomas, Fitts, R.H. Aging and skeletal muscle. 1981. In: Exercise and Aging: The Scientific Basis. E.L. Smith and R.C. Serfass, eds. Enslow Pub. Co., Winder, W.W., R.H. Fitts, J.O. Holloszy, K.K. Kaiser, M.H. Brooke. 1980. Effect of thyroid hormones on different types of skeletal muscle. In: Plasticity of Muscle, Ed. D. Pette. Pub. Walter de Gruyter Daniels, R.H. Fitts, G. Sheehan. 1978. The Scientific Aspects of Distance Running. John Wiley & Sons Inc. Pub. Holloszy, J.O., W.W. Winder, R.H. Fitts and M.J. Rennie. 1978. Postexercise ketosis: Protective effect of training. In: Biochemical and Clinical Aspects of Ketone Body Metabolism. Hans-Dieter Soling and Claus-Dieter Seufert (eds.). G. Thiems Pub., Fitts, R.H. 1977. The effects of exercise-training on the development of fatigue. The Annals of the Holloszy, J.O, W.W. Winder, R.H. Fitts, M.J. Rennie, R.C. Hickson, R.K. Conlee. 1976. Energy production during exercise. In: 3rd International Symposium on Biochemistry of Exercise, F. Landry and W.A.R. Orban (eds.). Symposia Specialists, Holloszy, J.O., F.W. Booth, W.W. Winder, R.H. Fitts. 1975. Biochemical adaptation of skeletal muscle to prolonged exercise. In: Metabolic Adaptation to Prolonged Exercise, 2nd International Symposium on Biochemistry of Exercise, H. Howald (editor). Birkhauser Verlag Basal.
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