Courses:

BIOL. 125.  Genetics. Analysis of the mechanisms of inheritance. Mendelian genetics and genetic mapping are related to the chromosome mechanics and molecular biology in which they are grounded.  Emphasis on organisms with special advantages as model genetic systems.

Lecture Topics for Biology 125 - Genetics

Part I. The nature of genes and mutagenesis

Part II. Chromosome Mechanics and Eukaryotic Gene Mapping

Mitosis and Meiosis
Chromosome theory of inheritance, Pedigree analysis
Law of Independent Assortment
Extensions to Mendel II: Multifactorial traits, Interacting genes, Complementary gene action, Epistasis
Genetic linkage, Chi-squared test
Crossing over and Recombination
Gene conversion
Recombination Frequency and Gene Mapping
Tetrad analysis I. Mapping two genes
Tetrad analysis II: Mapping a gene relative to its centromere
Chromosome abnormalities I: Polytene chromosomes, Deletion mapping, Duplications
Chromosomes abnormalities II Translocations and inversions

Part III. Nonmendelian Inheritance: Prokaryotes and Organelles

Mapping the prokaryotic genome I: Bacterial Conjugation
Mapping the prokaryotic genome II: Transduction
Cytoplasmic inheritance

Part IV. Molecular Genetics

Restriction enzymes
Molecular cloning
Human Genome Project & Applications
Polymerase Chain Reaction
DNA sequencing

Part V. Model Genetic Systems: Transgenic organisms

Saccharomyces cerevisiae: Genetic knockouts
Arabidopsis: Insertional mutagenesis
Caenorhabditis elegans: Hermaphrodite genetics, RNA interference
Drosophila melanogaster: P elements
Mouse

Part VI. Genetics of Populations

Population Genetics
Hardy-Weinberg equation
Evolution

Blast Search Exercise

BIOL. 255.  Eukaryotic Genetics and Chromosome Structure.  Focus on genetic approaches to the analysis of contemporary biological problems.

kathleen.karrer@marquette.edu